Tetraisopropyl Methylenediphosphonate is used in the preparation of E2-bisphosphonate conjugates as potential anti-osteoporosis agents. Also used in the preparation of AZT 5тАЩ-Triphosphate compounds which display inhibitory effects on HIV-1 reverse transcrpitase.
Wang, G. et al.: J. Med. Chem., 47, 6902 (2004); Gil, L. et al.: Bioorg. Med. Chem., 7, 901 (1999);
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