Chloroacetaldehyde Diethyl Acetal is a reagent for the preparation of thiopene-anthranilamides which is a highly potent and orally available factor Xa inhibitor.
Ye, B., et al.: J. Med. Chem., 50, 2967 (2007); Hirsh, J., et al.: Arch. Int. Med., 154, 282 (1994)