Benzothiohydrazide
:
纯度:98%
CAS:
英文名称:Benzothiohydrazide
Smiles Code
NNC(C=CC=CC=C)=S
苯硫代酰肼是异烟肼的类似物。苯硫代酰肼具有抗结核活性,对结核分枝杆菌的 MIC 分别为 3 μM 和 64 μM。
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[]. J. Laborde, et al. Synthesis, oxidation potential and anti–mycobacterial activity of isoniazid and analogues: insights into the molecular isoniazid activation mechanism. ChemistrySelect, (), 7–79.
P6-P64-P70-P7-P80-P30+P35-P304+P340-P330-P36-P405-P50
的合成线路
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~70%
参考文献:
Kalinowski, Danuta S. Sharpe, Philip C. Bernhardt, Paul V. Richardson, Des R. Journal of Medicinal Chemistry, 007 , vol. 50, # 4 p. 6 - 65
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~9%
参考文献:
ELI LILLY AND COMPANY Patent: WO005/984 A, 005 Location in patent: Page/Page column 4 WO 005/0984 A
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~%
参考文献:
Jensen,K.A. Pedersen,C. Acta Chemica Scandinavica (947-973), 96 , vol. 5, p. 097 - 03
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~9%
参考文献:
El-Barbary, A. A. Scheibye, S. Lawesson, S.-O. Fritz, H. Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 980 , vol. 34, # 8 p. 597 - 60
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~%
参考文献:
Stillings, Michael R. Welbourn, Anthony P. Walter, Donald S. Journal of Medicinal Chemistry, 986 , vol. 9, # p. 80 - 84
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